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  Thyroid Science 6(1):1-3, 2011

Outcome of Fixed and Uncalculated Dose of Radioiodine
in the Treatment of Hyper Functioning Thyroid Nodules


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Morteza Taghavi, MD
1 and Hatami Ghazal, MD2

1Assistant Professor of Endocrinology, Endocrine Research Center
Mashhad Medical University, Ahmad Abad Street, Ghaem Hospital, Mashhad, Iran

2Hatami Ghazal, MD
Ahmad Abad Street, Ghaem Hospital, Mashhad, Iran

Corresponding author: Morteza Taghavi, MD
Assistant Professor of Endocrinology, Endocrine Research Center
Mashhad Medical University, Ahmad Abad Street, Ghaem Hospital, Mashhad, Iran
Phone: 00989155164037 Fax: 00985118406757
mortezataghavi2003@yahoo.com  and taghaviMR@mums.ac.ir

Abstract. Introduction: This is a prospective study of patients treated for a solitary toxic nodule with a fixed dose of radioiodine (131I) and followed for at least 1 year in Mashhad, north east of Iran. Methods: We evaluated 780 patients who presented to the university hospital of Ghaem during a 7-year period because they had at least one thyroid nodule. We found hot thyroid nodules in 95 (12%) patients. Of these patients, 86 (90.5%) were female and 9 (9.5%) were male. Sixty-nine (72.6%) of the patients had thyrotoxicosis and 26 (27.4%) were euthyroid. We treated 49 thyrotoxic patients with 131I and followed them for a minimum of 12 months. The 131I dose for all patients was 15 mCi. The patients underwent thyroid function testing before treatment, at 6 months after treatment, and, thereafter, once every year. Results: The single fix dose (15 mCi) of radioiodine was sufficient to control hyperthyroidism in most patients (46/49, 93.8%) in 6 months. Because of persistent hyperthyroidism 6 months after the first dose, 3 patients (6.2%) required a second dose. Conclusion: A cure rate of 93.8% can occur within 6 months with a fixed and uncalculated dose of radioiodine. This result is similar to the results of treatment with calculated dose of radioiodine.

Keywords
Hot thyroid nodule Radioiodine Thyrotoxicosis


Citation: Taghavi, M. and Ghaza, H.: Outcome of Fixed and Uncalculated Dose of Radioiodine in the Treatment of Hyper Functioning Thyroid Nodules. Thyroid Science, 6(1):1-3, 2011.

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2011 Thyroid Science